Here's a list of our more recent publications, and those with our collaborators. For all those papers which are published as open access (freely available) we've put a link so you can download the full paper without having to hunt around for the journal, or you can follow the links to PubMed. If you want fuller information you can click here for a link to Tim Warner's Google Scholar page which gives a full list of Tim's publications, citations, impacts, etc.
Serotonin-affecting antidepressant use in relation to platelet reactivity. Grech J, Chan MV, Ochin C, Lachapelle A, Thibord F, Schneider Z, Nkambule BB, Armstrong PCJ, de Melendez CW, Tucker KL, Garelnabi M, Warner TD, Chen MH, Johnson AD. Clin Pharmacol Ther. 2021 Dec 22. doi: 10.1002/cpt.2517.
Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity. Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C, Willeit P, Santer P, Barwari T, Theofilatos K, Kiechl S, Willeit J, Warner TD, Mathur A, Mayr M.Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):49-62. doi: 10.1161/ATVBAHA.121.317113.
Proteome and functional decline as platelets age in the circulation. Allan HE, Hayman MA, Marcone S, Chan MV, Edin ML, Maffucci T, Joshi A, Menke L, Crescente M, Mayr M, Zeldin DC, Armstrong PC, Warner TD. J Thromb Haemost. 2021 Dec;19(12):3095-3112. doi: 10.1111/jth.15496.
Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators. Shih CC, Chan MV, Kirkby NS, Vojnovic I, Mitchell JA, Armstrong PC, Warner TD. Br J Pharmacol. 2021 Dec;178(23):4758-4771. doi: 10.1111/bph.15659.
A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis. Palma-Barqueros V, Crescente M, de la Morena ME, Chan MV, Almarza E, Revilla N, Bohdan N, Miñano A, Padilla J, Allan HE, Maffucci T, Edin ML, Zeldin DC, Mesa-Nuñez C, Damian C, Marín-Quilez A, Benito R, Martínez-Martínez I, Bermejo N, Casas-Aviles I, Rodríguez-Alen A, González-Porras JR, Hernández-Rivas JM, Vicente V, Corral J, Lozano ML, Warner TD, Bastida JM, Rivera J. Am J Hematol. 2021 Mar 1;96(3):E83-E88. doi: 10.1002/ajh.26076.
Cyclooxygenases and the cardiovascular system. Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD. Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624.
Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin. Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T, Allan HE, Mein CA, Gaston-Massuet C, Cottrell GS, Mitchell JA, Zeldin DC, Herschman HR, Warner TD. FASEB J. 2020 Aug;34(8):10027-10040. doi: 10.1096/fj.202000312R.
Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients. Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE, Brohi K, Armstrong PC. Blood Adv. 2020 Jun 23;4(12):2623-2630. doi: 10.1182/bloodadvances.2020001776
Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age. Chan MV, Chen MH, Barwari T, Huffman JE, Armstrong PC, Hwang SJ, Santer P, Wierer B, Mayr M, Kiechl S, Johnson AD, Willeit J, Warner TD. Circ Res. 2020 Apr 27. doi: 10.1161/CIRCRESAHA.119.316324
Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function. Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL, Stephens J, Greene D, Hanif M, O'Donnell VB, Dong L, Malkowski MG, Lentaigne C, Wedderburn K, Stubbs M, Downes K, Ouwehand WH, Turro E; NIHR BioResource, Hart DP, Freson K, Laffan MA, Warner TD. Haematologica. 2020 Apr 16. pii: haematol.2019.235895. doi: 10.3324/haematol.2019.235895.
Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy. Armstrong PC, Ferreira PM, Chan MV, Lundberg Slingsby MH, Crescente M, Shih CC, Kirkby NS, Hobbs AJ, Warner TD. J Thromb Haemost. 2020 Apr 11. doi: 10.1111/jth.14826.
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Hypoxia Modulates Platelet Purinergic Signalling Pathways. Paterson GG, Young JM, Willson JA, Graham CJ, Dru RC, Lee EW, Torpey GS, Walmsley SR, Chan MV, Warner TD, Baillie JK, Thompson AAR. Thromb Haemost. 2020 Feb;120(2):253-261. doi: 10.1055/s-0039-3400305.
Cell-Specific Gene Deletion Reveals the Anti-Thrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox. Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR, Kirkby NS. Circ Res. 2019 Sep 12. doi: 10.1161/CIRCRESAHA.119.314927.
Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage. Vulliamy P, Gillespie S, Armstrong PC, Allan HE, Warner TD, Brohi K. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17444-17449. doi: 10.1073/pnas.1904978116.
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B, Watson K, Armstrong PC, Mitchell JA, Warner TD, Ridley AJ, Muschel RJ. J Clin Invest. 2019 Mar 25;130:1845-1862. doi: 10.1172/JCI121985.
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Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy. Knowles RB, Warner TD. Pharmacol Ther. 2019 Jan;193:83-90. doi: 10.1016/j.pharmthera.2018.08.004.
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Inhibition of profibrotic microRNA-21 affects platelets and their releasate. Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. JCI Insight. 2018 Nov 2;3(21). pii: 123335. doi: 10.1172/jci.insight.123335.
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Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. Chan MV, Leadbeater PD, Watson SP, Warner TD. Platelets. 2018 May 1:1-4. doi: 10.1080/09537104.2018.1466388
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96-well plate-based aggregometry. Chan MV, Armstrong PC, Warner TD. Platelets. 2018 Nov;29(7):650-655. doi: 10.1080/09537104.2018.1445838.
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Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD. Br J Pharmacol. 2018 Mar 7. doi: 10.1111/bph.14196.
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Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M. Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD. Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144.
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Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels. Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, Chan MV, Armstrong PC, Warner TD, Hellsten Y. Acta Physiol (Oxf). 2018 Jan 3. doi: 10.1111/apha.13028.
Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice. Carrier É, Houde M, Grandbois M, Bkaily G, Warner TD, D'Orléans-Juste P. Can J Physiol Pharmacol. 2017 Aug;95(8):954-960.
Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M, Yaqoob P, Warner TD, Jones CI, Gibbins JM. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1482-1493.
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Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties. Knowles RB, Lawrence MJ, Ferreira PM, Hayman MA, D'Silva LA, Stanford SN, Sabra A, Tucker AT, Hawkins KM, Williams PR, Warner TD, Evans PA. Platelets. 2018;29:162-170.
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Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies. Armstrong PC, Hoefer T, Knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD. Arterioscler Thromb Vasc Biol. 2017 May;37(5):949-956.
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Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing. Ahmetaj-Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan MV, Gashaw H, Galaris G, Mazi S, Warner TD, Kirkby NS, Mitchell JA. Biochem Biophys Res Commun. 2017 Mar 18;484(4):762-766.
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ISTH Advanced Training Course on platelet bleeding disorders: How should they be investigated?St. Anne's College, Oxford, 6-9th September 2016. Watson SP, Daly ME, Harrison P, Lowe GC, Paterson A, Rivera J, Warner TD, Morgan NV. Platelets. 2016 Dec;27(8):719-721.
Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1. Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD. FASEB J. 2016 Sep 15. pii: fj.201600530R.
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Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid. Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA, Lauder SN, Allen-Redpath K, Collins PW, Murphy RC, Thomas CP, O'Donnell VB. J Biol Chem. 2016 Jun 24;291(26):13448-64. doi: 10.1074/jbc.M115.700609.
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The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy. Warner TD, Armstrong PC, Chan MV, Knowles RB. Expert Rev Hematol. 2016 Mar;9(3):223-5. doi: 10.1586/17474086.2016.1140035.
Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function. Floyd CN, Ferro A, Warner TD. JRSM Cardiovasc Dis. 2015 Nov 3;4:2048004015610252. doi: 10.1177/20480040156102
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Association of MicroRNAs and YRNAs With Platelet Function. Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Circ Res. 2016 Feb 5;118(3):420-32. doi: 10.1161/CIRCRESAHA.114.305663.
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P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation. Chan MV, Knowles RB, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PC, Mitchell JA, Warner TD. Br J Clin Pharmacol. 2016 Apr;81(4):621-33. doi: 10.1111/bcp.12826.
Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy. Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD. Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2122-33. doi: 10.1161/ATVBAHA.115.306219.
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Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Armstrong PC, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD. Blood. 2015 Sep 3;126(10):e11-8. doi: 10.1182/blood-2015-01-621656.
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Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation. Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD. FASEB J. 2015 Nov;29(11):4568-78. doi: 10.1096/fj.15-275065.
Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation. Rull G, Mohd-Zain ZN, Shiel J, Lundberg MH, Collier DJ, Johnston A, Warner TD, Corder R. Vascul Pharmacol. 2015 Aug;71:70-8. doi: 10.1016/j.vph.2015.02.010.
Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography. Khanna V, Armstrong PC, Warner TD, Curzen N. Platelets. 2015;26(7):689-92. doi: 10.3109/09537104.2014.1001832.
Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach. Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T, Elkin S, Kon OM, Hansel TT, Paul-Clark MJ. BMJ Open. 2015 Jan 28;5(1):e005750. doi: 10.1136/bmjopen-2014-005750.
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Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs. Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA. Circulation. 2015 Feb 17;131(7):633-42. doi: 10.1161/CIRCULATIONAHA.114.011591.
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COX-2 Protects against Atherosclerosis Independently of Local Vascular Prostacyclin: Identification of COX-2 Associated Pathways Implicate Rgl1 and Lymphocyte Networks. Kirkby NS, Lundberg MH, Wright WR, Warner TD, Paul-Clark MJ, Mitchell JA. PLoS One. 2014 Jun 2;9(6):e98165. doi: 10.1371/journal.pone.0098165.
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Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay. Lordkipanidzé M, Lowe GC, Kirkby NS, Chan MV, Lundberg MH, Morgan NV, Bem D, Nisar SP, Leo VC, Jones ML, Mundell SJ, Daly ME, Mumford AD, Warner TD, Watson SP; UK Genotyping and Phenotyping of Platelets Study Group. Blood. 2014 Feb 20;123(8):e11-22. doi: 10.1182/blood-2013-08-520387.
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Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP, MacDonald TT. Gut. 2014 Jan;63(1):96-104. doi: 10.1136/gutjnl-2012-303581.
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Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. d'Emmanuele di Villa Bianca R, Mitidieri E, Di Minno MN, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15812-7. doi: 10.1073/pnas.1309049110.
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Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide. Kirkby NS, Lundberg MH, Chan MV, Vojnovic I, Solomon AB, Emerson M, Mitchell JA, Warner TD. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15782-7.
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Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Kirkby NS, Zaiss AK, Wright WR, Jiao J, Chan MV, Warner TD, R Herschman H, Mitchell JA. Biochem Biophys Res Commun. 2013 Aug 23;438(2):249-56. doi: 10.1016/j.bbrc.2013.07.006. Epub 2013 Jul 11.
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LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Al-Yamani M, Lundberg MH, MacKenzie LS, Warner TD, Nicolaou A, Herschman HR, Mitchell JA. PLoS One. 2013 Jul 9;8(7):e69524. doi: 10.1371/journal.pone.0069524. Print 2013.
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Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test. Kirkby NS, Chan MV, Lundberg MH, Massey KA, Edmands WM, MacKenzie LS, Holmes E, Nicolaou A, Warner TD, Mitchell JA.
FASEB J. 2013 Oct;27(10):3938-46. doi: 10.1096/fj.12-215533.
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High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition. Björkman JA, Zachrisson H, Forsberg GB, von Bahr H, Hansson GI, Warner TD, Nylander S. Thromb Res. 2013 Apr;131(4):313-9. doi: 10.1016/j.thromres.2013.01.029.
Circulating microRNAs as novel biomarkers for platelet activation. Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, Sivaprasad S, Markus HS, Mitchell JA, Warner TD, Kiechl S, Mayr M. Circ Res. 2013 Feb 15;112(4):595-600. doi: 10.1161/CIRCRESAHA.111.300539.
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Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system. Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17597-602. doi: 10.1073/pnas.1209192109. Erratum in: Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1561.
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Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers. Andersson T, Morrison D, Nagy P, Pisupati J, Schettler J, Warner TD. Am J Cardiovasc Drugs. 2012 Aug 1;12(4):217-24. doi: 10.2165/11634280-000000000-00000.
Smoking, atherothrombosis and clopidogrel. Warner TD, Paul-Clark M, Mitchell JA. Heart. 2012 Jul;98(13):963-4. doi: 10.1136/heartjnl-2012-301903.
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Short thromboelastography and the identification of high platelet reactivity while on and off therapy. Warner TD, Mitchell JA, Kirkby NS. Heart. 2012 May;98(9):679-80. doi: 10.1136/heartjnl-2012-301676.
Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings. Chan MV, Warner TD. Platelets. 2012;23(5):404-8. doi: 10.3109/09537104.2011.603066.
Gasotransmitters and platelets. Truss NJ, Warner TD. Pharmacol Ther. 2011 Nov;132(2):196-203. doi: 10.1016/j.pharmthera.2011.07.001. Review.
Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. Warner TD, Nylander S, Whatling C. Br J Clin Pharmacol. 2011 Oct;72(4):619-33. doi: 10.1111/j.1365-2125.2011.03943.x. Review.
Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel. Kirkby NS, Leadbeater PD, Chan MV, Nylander S, Mitchell JA, Warner TD. J Thromb Haemost. 2011 Oct;9(10):2103-5. doi: 10.1111/j.1538-7836.2011.04453.x.
Aspirin has little additional anti-platelet effect in healthy volunteers receiving prasugrel. Leadbeater PD, Kirkby NS, Thomas S, Dhanji AR, Tucker AT, Milne GL, Mitchell JA, Warner TD. J Thromb Haemost. 2011 Oct;9(10):2050-6. doi: 10.1111/j.1538-7836.2011.04450.x.
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation. Armstrong PC, Leadbeater PD, Chan MV, Kirkby NS, Jakubowski JA, Mitchell JA, Warner TD. J Thromb Haemost. 2011 Mar;9(3):552-61. doi: 10.1111/j.1538-7836.2010.04160.x.
Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Chan MV, Armstrong PC, Papalia F, Kirkby NS, Warner TD. Platelets. 2011;22(7):485-94. doi: 10.3109/09537104.2011.592958.
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. Armstrong PC, Kirkby NS, Zain ZN, Emerson M, Mitchell JA, Warner TD. PLoS One. 2011;6(5):e20062. doi: 10.1371/journal.pone.0020062.
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Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists? Warner TD, Armstrong PC, Curzen NP, Mitchell JA. Heart. 2010 Nov;96(21):1693-4. doi: 10.1136/hrt.2010.205724.
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Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy. Armstrong PC, Dhanji AR, Tucker AT, Mitchell JA, Warner TD. J Thromb Haemost. 2010 Mar;8(3):613-5. doi: 10.1111/j.1538-7836.2009.03714.x.
PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report. Ali FY, Hall MG, Desvergne B, Warner TD, Mitchell JA. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1871-3. doi: 10.1161/ATVBAHA.109.193367.
Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods. Truss NJ, Armstrong PC, Liverani E, Vojnovic I, Warner TD. J Thromb Haemost. 2009 Nov;7(11):1897-905. doi: 10.1111/j.1538-7836.2009.03589.x.
The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ, Warner TD, Bishop-Bailey D. PLoS One. 2009 Oct 12;4(10):e7421. doi: 10.1371/journal.pone.0007421.
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Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness. Armstrong PC, Dhanji AR, Truss NJ, Zain ZN, Tucker AT, Mitchell JA, Warner TD. Thromb Haemost. 2009 Oct;102(4):772-8. doi: 10.1160/TH09-04-0215.
Rapid and accurate method for the von Willebrand factor ristocetin cofactor assay using 96-well microtiter plates. Truss NJ, Beavis J, MacCallum PK, Harrison P, Warner TD. J Thromb Haemost. 2009 Jul;7(7):1226-8. doi: 10.1111/j.1538-7836.2009.03466.x.
Antiplatelet actions of statins and fibrates are mediated by PPARs. Ali FY, Armstrong PC, Dhanji AR, Tucker AT, Paul-Clark MJ, Mitchell JA, Warner TD. Arterioscler Thromb Vasc Biol. 2009 May;29(5):706-11. doi: 10.1161/ATVBAHA.108.183160.
Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2. Armstrong PC, Truss NJ, Ali FY, Dhanji AA, Vojnovic I, Zain ZN, Bishop-Bailey D, Paul-Clark MJ, Tucker AT, Mitchell JA, Warner TD. J Thromb Haemost. 2008 Nov;6(11):1933-43. doi: 10.1111/j.1538-7836.2008.03133.x.Cyclooxygenases and the cardiovascular system.Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD.Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624. Epub 2020 Jul 5.PMID: 32640277
Neutrophil-Derived Protein S100A8/A9 Alters the Platelet Proteome in Acute Myocardial Infarction and Is Associated With Changes in Platelet Reactivity. Joshi A, Schmidt LE, Burnap SA, Lu R, Chan MV, Armstrong PC, Baig F, Gutmann C, Willeit P, Santer P, Barwari T, Theofilatos K, Kiechl S, Willeit J, Warner TD, Mathur A, Mayr M.Arterioscler Thromb Vasc Biol. 2022 Jan;42(1):49-62. doi: 10.1161/ATVBAHA.121.317113.
Proteome and functional decline as platelets age in the circulation. Allan HE, Hayman MA, Marcone S, Chan MV, Edin ML, Maffucci T, Joshi A, Menke L, Crescente M, Mayr M, Zeldin DC, Armstrong PC, Warner TD. J Thromb Haemost. 2021 Dec;19(12):3095-3112. doi: 10.1111/jth.15496.
Platelet inhibition by P2Y12 antagonists is potentiated by adenosine signalling activators. Shih CC, Chan MV, Kirkby NS, Vojnovic I, Mitchell JA, Armstrong PC, Warner TD. Br J Pharmacol. 2021 Dec;178(23):4758-4771. doi: 10.1111/bph.15659.
A novel genetic variant in PTGS1 affects N-glycosylation of cyclooxygenase-1 causing a dominant-negative effect on platelet function and bleeding diathesis. Palma-Barqueros V, Crescente M, de la Morena ME, Chan MV, Almarza E, Revilla N, Bohdan N, Miñano A, Padilla J, Allan HE, Maffucci T, Edin ML, Zeldin DC, Mesa-Nuñez C, Damian C, Marín-Quilez A, Benito R, Martínez-Martínez I, Bermejo N, Casas-Aviles I, Rodríguez-Alen A, González-Porras JR, Hernández-Rivas JM, Vicente V, Corral J, Lozano ML, Warner TD, Bastida JM, Rivera J. Am J Hematol. 2021 Mar 1;96(3):E83-E88. doi: 10.1002/ajh.26076.
Cyclooxygenases and the cardiovascular system. Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD. Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624.
Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirin. Crescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T, Allan HE, Mein CA, Gaston-Massuet C, Cottrell GS, Mitchell JA, Zeldin DC, Herschman HR, Warner TD. FASEB J. 2020 Aug;34(8):10027-10040. doi: 10.1096/fj.202000312R.
Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients. Vulliamy P, Montague SJ, Gillespie S, Chan MV, Coupland LA, Andrews RK, Warner TD, Gardiner EE, Brohi K, Armstrong PC. Blood Adv. 2020 Jun 23;4(12):2623-2630. doi: 10.1182/bloodadvances.2020001776
Platelet Reactivity in Individuals Over 65 Years Old Is not Modulated by Age. Chan MV, Chen MH, Barwari T, Huffman JE, Armstrong PC, Hwang SJ, Santer P, Wierer B, Mayr M, Kiechl S, Johnson AD, Willeit J, Warner TD. Circ Res. 2020 Apr 27. doi: 10.1161/CIRCRESAHA.119.316324
Identification of a homozygous recessive variant in PTGS1 resulting in a congenital aspirin-like defect in platelet function. Chan MV, Hayman MA, Sivapalaratnam S, Crescente M, Allan HE, Edin ML, Zeldin DC, Milne GL, Stephens J, Greene D, Hanif M, O'Donnell VB, Dong L, Malkowski MG, Lentaigne C, Wedderburn K, Stubbs M, Downes K, Ouwehand WH, Turro E; NIHR BioResource, Hart DP, Freson K, Laffan MA, Warner TD. Haematologica. 2020 Apr 16. pii: haematol.2019.235895. doi: 10.3324/haematol.2019.235895.
Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy. Armstrong PC, Ferreira PM, Chan MV, Lundberg Slingsby MH, Crescente M, Shih CC, Kirkby NS, Hobbs AJ, Warner TD. J Thromb Haemost. 2020 Apr 11. doi: 10.1111/jth.14826.
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Hypoxia Modulates Platelet Purinergic Signalling Pathways. Paterson GG, Young JM, Willson JA, Graham CJ, Dru RC, Lee EW, Torpey GS, Walmsley SR, Chan MV, Warner TD, Baillie JK, Thompson AAR. Thromb Haemost. 2020 Feb;120(2):253-261. doi: 10.1055/s-0039-3400305.
Cell-Specific Gene Deletion Reveals the Anti-Thrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin Paradox. Mitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR, Kirkby NS. Circ Res. 2019 Sep 12. doi: 10.1161/CIRCRESAHA.119.314927.
Histone H4 induces platelet ballooning and microparticle release during trauma hemorrhage. Vulliamy P, Gillespie S, Armstrong PC, Allan HE, Warner TD, Brohi K. Proc Natl Acad Sci U S A. 2019 Aug 27;116(35):17444-17449. doi: 10.1073/pnas.1904978116.
Aspirin blocks formation of metastatic intravascular niches by inhibiting platelet-derived COX-1/thromboxane A2. Lucotti S, Cerutti C, Soyer M, Gil-Bernabé AM, Gomes AL, Allen PD, Smart S, Markelc B, Watson K, Armstrong PC, Mitchell JA, Warner TD, Ridley AJ, Muschel RJ. J Clin Invest. 2019 Mar 25;130:1845-1862. doi: 10.1172/JCI121985.
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Anti-platelet drugs and their necessary interaction with endothelial mediators and platelet cyclic nucleotides for therapeutic efficacy. Knowles RB, Warner TD. Pharmacol Ther. 2019 Jan;193:83-90. doi: 10.1016/j.pharmthera.2018.08.004.
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Inhibition of profibrotic microRNA-21 affects platelets and their releasate. Barwari T, Eminaga S, Mayr U, Lu R, Armstrong PC, Chan MV, Sahraei M, Fernández-Fuertes M, Moreau T, Barallobre-Barreiro J, Lynch M, Yin X, Schulte C, Baig F, Pechlaner R, Langley SR, Zampetaki A, Santer P, Weger M, Plasenzotti R, Schosserer M, Grillari J, Kiechl S, Willeit J, Shah AM, Ghevaert C, Warner TD, Fernández-Hernando C, Suárez Y, Mayr M. JCI Insight. 2018 Nov 2;3(21). pii: 123335. doi: 10.1172/jci.insight.123335.
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Not all light transmission aggregation assays are created equal: qualitative differences between light transmission and 96-well plate aggregometry. Chan MV, Leadbeater PD, Watson SP, Warner TD. Platelets. 2018 May 1:1-4. doi: 10.1080/09537104.2018.1466388
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96-well plate-based aggregometry. Chan MV, Armstrong PC, Warner TD. Platelets. 2018 Nov;29(7):650-655. doi: 10.1080/09537104.2018.1445838.
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Eicosanoids in platelets and the effect of their modulation by aspirin in the cardiovascular system (and beyond). Crescente M, Menke L, Chan MV, Armstrong PC, Warner TD. Br J Pharmacol. 2018 Mar 7. doi: 10.1111/bph.14196.
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Kidney Transplantation in a Patient Lacking Cytosolic Phospholipase A2 Proves Renal Origins of Urinary PGI-M and TX-M. Mitchell JA, Knowles RB, Kirkby NS, Reed DM, Edin ML, White WE, Chan MV, Longhurst H, Yaqoob MM, Milne GL, Zeldin DC, Warner TD. Circ Res. 2018 Feb 16;122(4):555-559. doi: 10.1161/CIRCRESAHA.117.312144.
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Platelet responses to pharmacological and physiological interventions in middle-aged men with different habitual physical activity levels. Lundberg Slingsby MH, Gliemann L, Thrane M, Rytter N, Egelund J, Chan MV, Armstrong PC, Warner TD, Hellsten Y. Acta Physiol (Oxf). 2018 Jan 3. doi: 10.1111/apha.13028.
Inhibition of platelet aggregation ex vivo is repressed in apolipoprotein E deficient mice. Carrier É, Houde M, Grandbois M, Bkaily G, Warner TD, D'Orléans-Juste P. Can J Physiol Pharmacol. 2017 Aug;95(8):954-960.
Farnesoid X Receptor and Liver X Receptor Ligands Initiate Formation of Coated Platelets. Unsworth AJ, Bye AP, Tannetta DS, Desborough MJR, Kriek N, Sage T, Allan HE, Crescente M, Yaqoob P, Warner TD, Jones CI, Gibbins JM. Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1482-1493.
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Platelet reactivity influences clot structure as assessed by fractal analysis of viscoelastic properties. Knowles RB, Lawrence MJ, Ferreira PM, Hayman MA, D'Silva LA, Stanford SN, Sabra A, Tucker AT, Hawkins KM, Williams PR, Warner TD, Evans PA. Platelets. 2018;29:162-170.
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Newly Formed Reticulated Platelets Undermine Pharmacokinetically Short-Lived Antiplatelet Therapies. Armstrong PC, Hoefer T, Knowles RB, Tucker AT, Hayman MA, Ferreira PM, Chan MV, Warner TD. Arterioscler Thromb Vasc Biol. 2017 May;37(5):949-956.
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Pharmacological assessment of ibuprofen arginate on platelet aggregation and colon cancer cell killing. Ahmetaj-Shala B, Tesfai A, Constantinou C, Leszczynski R, Chan MV, Gashaw H, Galaris G, Mazi S, Warner TD, Kirkby NS, Mitchell JA. Biochem Biophys Res Commun. 2017 Mar 18;484(4):762-766.
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ISTH Advanced Training Course on platelet bleeding disorders: How should they be investigated?St. Anne's College, Oxford, 6-9th September 2016. Watson SP, Daly ME, Harrison P, Lowe GC, Paterson A, Rivera J, Warner TD, Morgan NV. Platelets. 2016 Dec;27(8):719-721.
Aspirin inhibits the production of proangiogenic 15(S)-HETE by platelet cyclooxygenase-1. Rauzi F, Kirkby NS, Edin ML, Whiteford J, Zeldin DC, Mitchell JA, Warner TD. FASEB J. 2016 Sep 15. pii: fj.201600530R.
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Human Platelets Utilize Cycloxygenase-1 to Generate Dioxolane A3, a Neutrophil-activating Eicosanoid. Hinz C, Aldrovandi M, Uhlson C, Marnett LJ, Longhurst HJ, Warner TD, Alam S, Slatter DA, Lauder SN, Allen-Redpath K, Collins PW, Murphy RC, Thomas CP, O'Donnell VB. J Biol Chem. 2016 Jun 24;291(26):13448-64. doi: 10.1074/jbc.M115.700609.
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The importance of endothelium-derived mediators to the efficacy of dual anti-platelet therapy. Warner TD, Armstrong PC, Chan MV, Knowles RB. Expert Rev Hematol. 2016 Mar;9(3):223-5. doi: 10.1586/17474086.2016.1140035.
Expression of the PlA2 allele of glycoprotein IIIa and its impact on platelet function. Floyd CN, Ferro A, Warner TD. JRSM Cardiovasc Dis. 2015 Nov 3;4:2048004015610252. doi: 10.1177/20480040156102
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Association of MicroRNAs and YRNAs With Platelet Function. Kaudewitz D, Skroblin P, Bender LH, Barwari T, Willeit P, Pechlaner R, Sunderland NP, Willeit K, Morton AC, Armstrong PC, Chan MV, Lu R, Yin X, Gracio F, Dudek K, Langley SR, Zampetaki A, de Rinaldis E, Ye S, Warner TD, Saxena A, Kiechl S, Storey RF, Mayr M. Circ Res. 2016 Feb 5;118(3):420-32. doi: 10.1161/CIRCRESAHA.114.305663.
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P2Y12 receptor blockade synergizes strongly with nitric oxide and prostacyclin to inhibit platelet activation. Chan MV, Knowles RB, Lundberg MH, Tucker AT, Mohamed NA, Kirkby NS, Armstrong PC, Mitchell JA, Warner TD. Br J Clin Pharmacol. 2016 Apr;81(4):621-33. doi: 10.1111/bcp.12826.
Drug-Free Platelets Can Act as Seeds for Aggregate Formation During Antiplatelet Therapy. Hoefer T, Armstrong PC, Finsterbusch M, Chan MV, Kirkby NS, Warner TD. Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2122-33. doi: 10.1161/ATVBAHA.115.306219.
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Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. Armstrong PC, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD. Blood. 2015 Sep 3;126(10):e11-8. doi: 10.1182/blood-2015-01-621656.
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Inherited human group IVA cytosolic phospholipase A2 deficiency abolishes platelet, endothelial, and leucocyte eicosanoid generation. Kirkby NS, Reed DM, Edin ML, Rauzi F, Mataragka S, Vojnovic I, Bishop-Bailey D, Milne GL, Longhurst H, Zeldin DC, Mitchell JA, Warner TD. FASEB J. 2015 Nov;29(11):4568-78. doi: 10.1096/fj.15-275065.
Effects of high flavanol dark chocolate on cardiovascular function and platelet aggregation. Rull G, Mohd-Zain ZN, Shiel J, Lundberg MH, Collier DJ, Johnston A, Warner TD, Corder R. Vascul Pharmacol. 2015 Aug;71:70-8. doi: 10.1016/j.vph.2015.02.010.
Prostaglandin E1 potentiates the effects of P2Y12 blockade on ADP-mediated platelet aggregation in vitro: Insights using short thromboelastography. Khanna V, Armstrong PC, Warner TD, Curzen N. Platelets. 2015;26(7):689-92. doi: 10.3109/09537104.2014.1001832.
Protocol for a human in vivo model of acute cigarette smoke inhalation challenge in smokers with COPD: monitoring the nasal and systemic immune response using a network biology approach. Ross CL, Galloway-Phillipps N, Armstrong PC, Mitchell JA, Warner TD, Brearley C, Ito M, Tunstall T, Elkin S, Kon OM, Hansel TT, Paul-Clark MJ. BMJ Open. 2015 Jan 28;5(1):e005750. doi: 10.1136/bmjopen-2014-005750.
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Evidence that links loss of cyclooxygenase-2 with increased asymmetric dimethylarginine: novel explanation of cardiovascular side effects associated with anti-inflammatory drugs. Ahmetaj-Shala B, Kirkby NS, Knowles R, Al'Yamani M, Mazi S, Wang Z, Tucker AT, Mackenzie L, Armstrong PC, Nüsing RM, Tomlinson JA, Warner TD, Leiper J, Mitchell JA. Circulation. 2015 Feb 17;131(7):633-42. doi: 10.1161/CIRCULATIONAHA.114.011591.
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COX-2 Protects against Atherosclerosis Independently of Local Vascular Prostacyclin: Identification of COX-2 Associated Pathways Implicate Rgl1 and Lymphocyte Networks. Kirkby NS, Lundberg MH, Wright WR, Warner TD, Paul-Clark MJ, Mitchell JA. PLoS One. 2014 Jun 2;9(6):e98165. doi: 10.1371/journal.pone.0098165.
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Characterization of multiple platelet activation pathways in patients with bleeding as a high-throughput screening option: use of 96-well Optimul assay. Lordkipanidzé M, Lowe GC, Kirkby NS, Chan MV, Lundberg MH, Morgan NV, Bem D, Nisar SP, Leo VC, Jones ML, Mundell SJ, Daly ME, Mumford AD, Warner TD, Watson SP; UK Genotyping and Phenotyping of Platelets Study Group. Blood. 2014 Feb 20;123(8):e11-22. doi: 10.1182/blood-2013-08-520387.
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Cryptogenic multifocal ulcerating stenosing enteritis associated with homozygous deletion mutations in cytosolic phospholipase A2-α. Brooke MA, Longhurst HJ, Plagnol V, Kirkby NS, Mitchell JA, Rüschendorf F, Warner TD, Kelsell DP, MacDonald TT. Gut. 2014 Jan;63(1):96-104. doi: 10.1136/gutjnl-2012-303581.
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Hydrogen sulphide pathway contributes to the enhanced human platelet aggregation in hyperhomocysteinemia. d'Emmanuele di Villa Bianca R, Mitidieri E, Di Minno MN, Kirkby NS, Warner TD, Di Minno G, Cirino G, Sorrentino R. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15812-7. doi: 10.1073/pnas.1309049110.
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Blockade of the purinergic P2Y12 receptor greatly increases the platelet inhibitory actions of nitric oxide. Kirkby NS, Lundberg MH, Chan MV, Vojnovic I, Solomon AB, Emerson M, Mitchell JA, Warner TD. Proc Natl Acad Sci U S A. 2013 Sep 24;110(39):15782-7.
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Differential COX-2 induction by viral and bacterial PAMPs: Consequences for cytokine and interferon responses and implications for anti-viral COX-2 directed therapies. Kirkby NS, Zaiss AK, Wright WR, Jiao J, Chan MV, Warner TD, R Herschman H, Mitchell JA. Biochem Biophys Res Commun. 2013 Aug 23;438(2):249-56. doi: 10.1016/j.bbrc.2013.07.006. Epub 2013 Jul 11.
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LC-MS/MS confirms that COX-1 drives vascular prostacyclin whilst gene expression pattern reveals non-vascular sites of COX-2 expression. Kirkby NS, Zaiss AK, Urquhart P, Jiao J, Austin PJ, Al-Yamani M, Lundberg MH, MacKenzie LS, Warner TD, Nicolaou A, Herschman HR, Mitchell JA. PLoS One. 2013 Jul 9;8(7):e69524. doi: 10.1371/journal.pone.0069524. Print 2013.
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Aspirin-triggered 15-epi-lipoxin A4 predicts cyclooxygenase-2 in the lungs of LPS-treated mice but not in the circulation: implications for a clinical test. Kirkby NS, Chan MV, Lundberg MH, Massey KA, Edmands WM, MacKenzie LS, Holmes E, Nicolaou A, Warner TD, Mitchell JA.
FASEB J. 2013 Oct;27(10):3938-46. doi: 10.1096/fj.12-215533.
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High-dose aspirin in dogs increases vascular resistance with limited additional anti-platelet effect when combined with potent P2Y12 inhibition. Björkman JA, Zachrisson H, Forsberg GB, von Bahr H, Hansson GI, Warner TD, Nylander S. Thromb Res. 2013 Apr;131(4):313-9. doi: 10.1016/j.thromres.2013.01.029.
Circulating microRNAs as novel biomarkers for platelet activation. Willeit P, Zampetaki A, Dudek K, Kaudewitz D, King A, Kirkby NS, Crosby-Nwaobi R, Prokopi M, Drozdov I, Langley SR, Sivaprasad S, Markus HS, Mitchell JA, Warner TD, Kiechl S, Mayr M. Circ Res. 2013 Feb 15;112(4):595-600. doi: 10.1161/CIRCRESAHA.111.300539.
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Cyclooxygenase-1, not cyclooxygenase-2, is responsible for physiological production of prostacyclin in the cardiovascular system. Kirkby NS, Lundberg MH, Harrington LS, Leadbeater PD, Milne GL, Potter CM, Al-Yamani M, Adeyemi O, Warner TD, Mitchell JA. Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17597-602. doi: 10.1073/pnas.1209192109. Erratum in: Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1561.
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Evaluation of the pharmacodynamics of acetylsalicylic acid 81 mg with or without esomeprazole 20 mg in healthy volunteers. Andersson T, Morrison D, Nagy P, Pisupati J, Schettler J, Warner TD. Am J Cardiovasc Drugs. 2012 Aug 1;12(4):217-24. doi: 10.2165/11634280-000000000-00000.
Smoking, atherothrombosis and clopidogrel. Warner TD, Paul-Clark M, Mitchell JA. Heart. 2012 Jul;98(13):963-4. doi: 10.1136/heartjnl-2012-301903.
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Short thromboelastography and the identification of high platelet reactivity while on and off therapy. Warner TD, Mitchell JA, Kirkby NS. Heart. 2012 May;98(9):679-80. doi: 10.1136/heartjnl-2012-301676.
Standardised optical multichannel (optimul) platelet aggregometry using high-speed shaking and fixed time point readings. Chan MV, Warner TD. Platelets. 2012;23(5):404-8. doi: 10.3109/09537104.2011.603066.
Gasotransmitters and platelets. Truss NJ, Warner TD. Pharmacol Ther. 2011 Nov;132(2):196-203. doi: 10.1016/j.pharmthera.2011.07.001. Review.
Anti-platelet therapy: cyclo-oxygenase inhibition and the use of aspirin with particular regard to dual anti-platelet therapy. Warner TD, Nylander S, Whatling C. Br J Clin Pharmacol. 2011 Oct;72(4):619-33. doi: 10.1111/j.1365-2125.2011.03943.x. Review.
Antiplatelet effects of aspirin vary with level of P2Y₁₂ receptor blockade supplied by either ticagrelor or prasugrel. Kirkby NS, Leadbeater PD, Chan MV, Nylander S, Mitchell JA, Warner TD. J Thromb Haemost. 2011 Oct;9(10):2103-5. doi: 10.1111/j.1538-7836.2011.04453.x.
Aspirin has little additional anti-platelet effect in healthy volunteers receiving prasugrel. Leadbeater PD, Kirkby NS, Thomas S, Dhanji AR, Tucker AT, Milne GL, Mitchell JA, Warner TD. J Thromb Haemost. 2011 Oct;9(10):2050-6. doi: 10.1111/j.1538-7836.2011.04450.x.
In the presence of strong P2Y12 receptor blockade, aspirin provides little additional inhibition of platelet aggregation. Armstrong PC, Leadbeater PD, Chan MV, Kirkby NS, Jakubowski JA, Mitchell JA, Warner TD. J Thromb Haemost. 2011 Mar;9(3):552-61. doi: 10.1111/j.1538-7836.2010.04160.x.
Optical multichannel (optimul) platelet aggregometry in 96-well plates as an additional method of platelet reactivity testing. Chan MV, Armstrong PC, Papalia F, Kirkby NS, Warner TD. Platelets. 2011;22(7):485-94. doi: 10.3109/09537104.2011.592958.
Thrombosis is reduced by inhibition of COX-1, but unaffected by inhibition of COX-2, in an acute model of platelet activation in the mouse. Armstrong PC, Kirkby NS, Zain ZN, Emerson M, Mitchell JA, Warner TD. PLoS One. 2011;6(5):e20062. doi: 10.1371/journal.pone.0020062.
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Dual antiplatelet therapy in cardiovascular disease: does aspirin increase clinical risk in the presence of potent P2Y12 receptor antagonists? Warner TD, Armstrong PC, Curzen NP, Mitchell JA. Heart. 2010 Nov;96(21):1693-4. doi: 10.1136/hrt.2010.205724.
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Reduction of platelet thromboxane A2 production ex vivo and in vivo by clopidogrel therapy. Armstrong PC, Dhanji AR, Tucker AT, Mitchell JA, Warner TD. J Thromb Haemost. 2010 Mar;8(3):613-5. doi: 10.1111/j.1538-7836.2009.03714.x.
PPARbeta/delta agonists modulate platelet function via a mechanism involving PPAR receptors and specific association/repression of PKCalpha--brief report. Ali FY, Hall MG, Desvergne B, Warner TD, Mitchell JA. Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1871-3. doi: 10.1161/ATVBAHA.109.193367.
Heparin but not citrate anticoagulation of blood preserves platelet function for prolonged periods. Truss NJ, Armstrong PC, Liverani E, Vojnovic I, Warner TD. J Thromb Haemost. 2009 Nov;7(11):1897-905. doi: 10.1111/j.1538-7836.2009.03589.x.
The epoxygenases CYP2J2 activates the nuclear receptor PPARalpha in vitro and in vivo. Wray JA, Sugden MC, Zeldin DC, Greenwood GK, Samsuddin S, Miller-Degraff L, Bradbury JA, Holness MJ, Warner TD, Bishop-Bailey D. PLoS One. 2009 Oct 12;4(10):e7421. doi: 10.1371/journal.pone.0007421.
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Utility of 96-well plate aggregometry and measurement of thrombi adhesion to determine aspirin and clopidogrel effectiveness. Armstrong PC, Dhanji AR, Truss NJ, Zain ZN, Tucker AT, Mitchell JA, Warner TD. Thromb Haemost. 2009 Oct;102(4):772-8. doi: 10.1160/TH09-04-0215.
Rapid and accurate method for the von Willebrand factor ristocetin cofactor assay using 96-well microtiter plates. Truss NJ, Beavis J, MacCallum PK, Harrison P, Warner TD. J Thromb Haemost. 2009 Jul;7(7):1226-8. doi: 10.1111/j.1538-7836.2009.03466.x.
Antiplatelet actions of statins and fibrates are mediated by PPARs. Ali FY, Armstrong PC, Dhanji AR, Tucker AT, Paul-Clark MJ, Mitchell JA, Warner TD. Arterioscler Thromb Vasc Biol. 2009 May;29(5):706-11. doi: 10.1161/ATVBAHA.108.183160.
Aspirin and the in vitro linear relationship between thromboxane A2-mediated platelet aggregation and platelet production of thromboxane A2. Armstrong PC, Truss NJ, Ali FY, Dhanji AA, Vojnovic I, Zain ZN, Bishop-Bailey D, Paul-Clark MJ, Tucker AT, Mitchell JA, Warner TD. J Thromb Haemost. 2008 Nov;6(11):1933-43. doi: 10.1111/j.1538-7836.2008.03133.x.Cyclooxygenases and the cardiovascular system.Mitchell JA, Kirkby NS, Ahmetaj-Shala B, Armstrong PC, Crescente M, Ferreira P, Lopes Pires ME, Vaja R, Warner TD.Pharmacol Ther. 2021 Jan;217:107624. doi: 10.1016/j.pharmthera.2020.107624. Epub 2020 Jul 5.PMID: 32640277